Protein-anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction

Acetylcholinesterase (AChE) at the neuromuscular junction (NMJ) is anchored to the synaptic basal lamina via a triple helical collagen Q (ColQ). Congenital defects of ColQ cause endplate AChE deficiency and myasthenic syndrome. A single intravenous administration of adeno-associated virus serotype 8...

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Detalhes bibliográficos
Main Authors: Ito, Mikako, Suzuki, Yumi, Okada, Takashi, Fukudome, Takayasu, Yoshimura, Toshiro, Masuda, Akio, Takeda, Shin'ichi, Krejci, Eric, Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392993/
https://ncbi.nlm.nih.gov/pubmed/22371845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.34
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