Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

INTRODUCTION: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a key negative costimulatory molecule that displays a wide range of anti-inflammatory properties and is currently approved to treat rheumatoid arthritis as a recombinant fusion protein (CTLA4IgG). To better understand the role of CTLA4IgG in...

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Main Authors: Yin, Hongen, Nguyen, Cuong Q, Samuni, Yuval, Uede, Toshimitsu, Peck, Ammon B, Chiorini, John A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392840/
https://ncbi.nlm.nih.gov/pubmed/22369699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3753
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