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Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Pax gene haploinsufficiency causes a variety of congenital defects. Renal-coloboma syndrome, resulting from mutations in Pax2, is characterized by kidney hypoplasia, optic nerve malformation, and hearing loss. Although this underscores the importance of Pax gene dosage in normal development, how dif...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Company of Biologists
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392703/ https://ncbi.nlm.nih.gov/pubmed/22745314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.076075 |
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