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Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4

Ectopic expression of defined sets of transcription factors in somatic cells enables them to adopt the qualities of pluripotency. Mouse embryonic fibroblasts (MEFs) are the classic target cell used to elucidate the core principles of nuclear reprogramming. However, their phenotypic and functional he...

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Autori principali: Nemajerova, A, Kim, S Y, Petrenko, O, Moll, U M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392633/
https://ncbi.nlm.nih.gov/pubmed/22539002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.45
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