Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

Fanconi anemia (FA) is an inherited DNA repair deficiency syndrome. FA patients undergo progressive bone marrow failure (BMF) during childhood, which frequently requires allogeneic hematopoietic stem cell transplantation. The pathogenesis of this BMF has been elusive to date. Here we found that FA p...

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Detalhes bibliográficos
Main Authors: Ceccaldi, Raphael, Parmar, Kalindi, Mouly, Enguerran, Delord, Marc, Kim, Jung Min, Regairaz, Marie, Pla, Marika, Vasquez, Nadia, Zhang, Qing-Shuo, Pondarre, Corinne, de Latour, Régis Peffault, Gluckman, Eliane, Cavazzana-Calvo, Marina, Leblanc, Thierry, Larghero, Jérôme, Grompe, Markus, Socié, Gérard, D'Andrea, Alan D., Soulier, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392433/
https://ncbi.nlm.nih.gov/pubmed/22683204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.05.013
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