Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

Fanconi anemia (FA) is an inherited DNA repair deficiency syndrome. FA patients undergo progressive bone marrow failure (BMF) during childhood, which frequently requires allogeneic hematopoietic stem cell transplantation. The pathogenesis of this BMF has been elusive to date. Here we found that FA p...

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Bibliografski detalji
Glavni autori: Ceccaldi, Raphael, Parmar, Kalindi, Mouly, Enguerran, Delord, Marc, Kim, Jung Min, Regairaz, Marie, Pla, Marika, Vasquez, Nadia, Zhang, Qing-Shuo, Pondarre, Corinne, de Latour, Régis Peffault, Gluckman, Eliane, Cavazzana-Calvo, Marina, Leblanc, Thierry, Larghero, Jérôme, Grompe, Markus, Socié, Gérard, D'Andrea, Alan D., Soulier, Jean
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392433/
https://ncbi.nlm.nih.gov/pubmed/22683204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.05.013
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