The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

In this study we report that, in response to proteasome inhibition, the E3-Ubiquitin ligase TRIM50 localizes to and promotes the recruitment and aggregation of polyubiquitinated proteins to the aggresome. Using Hdac6-deficient mouse embryo fibroblasts (MEF) we show that this localization is mediated...

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Bibliografiske detaljer
Main Authors: Fusco, Carmela, Micale, Lucia, Egorov, Mikhail, Monti, Maria, D’Addetta, Ester Valentina, Augello, Bartolomeo, Cozzolino, Flora, Calcagnì, Alessia, Fontana, Andrea, Polishchuk, Roman S., Didelot, Gerard, Reymond, Alexandre, Pucci, Piero, Merla, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392214/
https://ncbi.nlm.nih.gov/pubmed/22792322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040440
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