Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinson's disease

Parkinson's disease (PD) is the second most prevalent progressive neurological disorder commonly associated with impaired mitochondrial function in dopaminergic neurons. Although familial PD is multifactorial in nature, a recent genetic screen involving PD patients identified two mitochondrial...

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Hlavní autoři: Goswami, Arvind Vittal, Samaddar, Madhuja, Sinha, Devanjan, Purushotham, Jaya, D'Silva, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392108/
https://ncbi.nlm.nih.gov/pubmed/22544056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds162
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