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RNAi promotes heterochromatic silencing through replication-coupled release of RNA polII

Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification (1) during the DNA replication phase of the cell cycle(2). Here, we show that the alternati...

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Detalhes bibliográficos
Main Authors: Zaratiegui, Mikel, Castel, Stephane, Irvine, Danielle V., Kloc, Anna, Ren, Jie, Li, Fei, de Castro, Elisa, Marín, Laura, Chang, An-Yun, Goto, Derek, Cande, W. Zacheus, Antequera, Francisco, Arcangioli, Benoit, Martienssen, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391703/
https://ncbi.nlm.nih.gov/pubmed/22002604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10501
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