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Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII

In the biosynthesis of the clinically important antibiotic erythromycin D, the glycosyltransferase (GT) EryCIII, in concert with its partner EryCII, attaches a nucleotide-activated sugar to the macrolide scaffold with high specificity. To understand the role of EryCII, we have determined the crystal...

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Detalhes bibliográficos
Main Authors: Moncrieffe, Martin C., Fernandez, Maria-Jose, Spiteller, Dieter, Matsumura, Hiroyoshi, Gay, Nicholas J., Luisi, Ben F., Leadlay, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391682/
https://ncbi.nlm.nih.gov/pubmed/22056329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.036
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