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Activation of the aryl hydrocarbon receptor AhR promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4

Retinoic acid (RA) is used to treat leukemia and other cancers through its ability to promote cancer cell differentiation. Strategies to enhance the anti-cancer effects of RA could deepen and broaden its beneficial therapeutic applications. In this study, we describe a receptor crosstalk system that...

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Détails bibliographiques
Auteurs principaux: Bunaciu, Rodica P, Yen, Andrew
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391168/
https://ncbi.nlm.nih.gov/pubmed/21262915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2299
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