Lysophosphatidic Acid Induces Early Growth Response-1 (Egr-1) Protein Expression via Protein Kinase Cδ-regulated Extracellular Signal-regulated Kinase (ERK) and c-Jun N-terminal Kinase (JNK) Activation in Vascular Smooth Muscle Cells

Lysophosphatidic acid (LPA) modulates vascular cell function in vitro and in vivo via regulating the expression of specific genes. Previously, we reported that a transcriptional mechanism controls LPA-induced expression of Egr-1 in vascular smooth muscle cells. Egr-1 is a master transcription factor...

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Bibliographic Details
Main Authors: Iyoda, Takuya, Zhang, Fuqiang, Sun, Longsheng, Hao, Feng, Schmitz-Peiffer, Carsten, Xu, Xuemin, Cui, Mei-Zhen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391141/
https://ncbi.nlm.nih.gov/pubmed/22577133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335695
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