Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal Cells

Despite the identification of the 43 kDa transactive response DNA-binding protein (TDP-43) as a major pathological signatory protein in a wide range of neurodegenerative diseases, the mechanistic role of TDP-43 in neurodegenerative disorders is still poorly understood. Here, we report that TDP-43 is...

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Bibliografiske detaljer
Main Authors: Yu, Zhipeng, Fan, Dongsheng, Gui, Bin, Shi, Lei, Xuan, Chenghao, Shan, Lin, Wang, Qian, Shang, Yongfeng, Wang, Yan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391095/
https://ncbi.nlm.nih.gov/pubmed/22584570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357582
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