Sequential Proteolytic Processing of an Interferon-Alpha Receptor Subunit by TNF-Alpha Converting Enzyme and Presenilins

It is well established that interferons trigger tyrosine-kinase-dependent signaling via JAK kinases and STAT transcription factors. However, we have observed both IFNaR2 receptor cleavage and functional activity of the liberated intracellular domain (ICD), suggesting that interferon-alpha (IFN-alpha...

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Autors principals: Pioli, Peter D., Saleh, Abu M.Z., El Fiky, Ashraf, Nastiuk, Kent L., Krolewski, John J.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390988/
https://ncbi.nlm.nih.gov/pubmed/22458690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2011.0116
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