Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum

IL-15 is an important cytokine for the function of the immune system, but the form(s) of IL-15 produced in the human body are not fully characterized. Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Rα) in the same cell allows for efficient production, surface display, and...

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Main Authors: Bergamaschi, Cristina, Bear, Jenifer, Rosati, Margherita, Beach, Rachel Kelly, Alicea, Candido, Sowder, Raymond, Chertova, Elena, Rosenberg, Steven A., Felber, Barbara K., Pavlakis, George N.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390963/
https://ncbi.nlm.nih.gov/pubmed/22496150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-384362
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