Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function

Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here, we show that mice deficient in Eri1, a conserved 3′-to-5′ exoribonuclease that represses RNA interference, have a cell-intrinsic defect in NK-cell development and maturation. Eri1(−/−) NK ce...

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Detalhes bibliográficos
Main Authors: Thomas, Molly F., Abdul-Wajid, Sarah, Panduro, Marisella, Babiarz, Joshua E., Rajaram, Misha, Woodruff, Prescott, Lanier, Lewis L., Heissmeyer, Vigo, Ansel, K. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390952/
https://ncbi.nlm.nih.gov/pubmed/22613798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-394072
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