Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that temporal modulation of Wnt signaling is both essential and sufficient for efficient cardiac induction in hPSCs under define...

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Hlavní autoři: Lian, Xiaojun, Hsiao, Cheston, Wilson, Gisela, Zhu, Kexian, Hazeltine, Laurie B., Azarin, Samira M., Raval, Kunil K., Zhang, Jianhua, Kamp, Timothy J., Palecek, Sean P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390875/
https://ncbi.nlm.nih.gov/pubmed/22645348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200250109
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