Peroxisome Proliferator-activated Receptor γ Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression

Proprotein convertase subtilisin kexin type 9 (PCSK9) plays an important role in cholesterol homeostasis by enhancing the degradation of LDL receptor (LDLR) protein. Peroxisome proliferator-activated receptor γ (PPARγ) has been shown to be atheroprotective. PPARγ can be activated by ligands and/or d...

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Detalhes bibliográficos
Main Authors: Duan, Yajun, Chen, Yuanli, Hu, Wenquan, Li, Xiaoju, Yang, Xiaoxiao, Zhou, Xin, Yin, Zhinan, Kong, Deling, Yao, Zhi, Hajjar, David P., Liu, Lin, Liu, Qiang, Han, Jihong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390641/
https://ncbi.nlm.nih.gov/pubmed/22593575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350181
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