ATP Depletion Triggers Acute Myeloid Leukemia Differentiation through an ATR/Chk1 Protein-dependent and p53 Protein-independent Pathway

Despite advances in oncology drug development, most commonly used cancer therapeutics exhibit serious adverse effects. Often the toxicities of chemotherapeutics are due to the induction of significant DNA damage that is necessary for their ability to kill cancer cells. In some clinical situations, t...

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Main Authors: Chakrabarti, Amitabha, Gupta, Kalpana, Sharma, James Prabhakar, Yang, Jinbo, Agarwal, Anju, Glick, Abigail, Zhang, Youwei, Agarwal, Munna, Agarwal, Mukesh K., Wald, David N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390638/
https://ncbi.nlm.nih.gov/pubmed/22621920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312801
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