Expression of a Truncated Form of the Endoplasmic Reticulum Chaperone Protein, σ1 Receptor, Promotes Mitochondrial Energy Depletion and Apoptosis

The σ1 receptor (σ(1)R) regulates endoplasmic reticulum (ER)/mitochondrial interorganellar Ca(2+) mobilization through the inositol 1,4,5-trisphosphate receptor (IP(3)R). Here, we observed that expression of a novel splice variant of σ(1)R, termed short form σ(1)R (σ(1)SR), has a detrimental effect...

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Autors principals: Shioda, Norifumi, Ishikawa, Kiyoshi, Tagashira, Hideaki, Ishizuka, Toru, Yawo, Hiromu, Fukunaga, Kohji
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390610/
https://ncbi.nlm.nih.gov/pubmed/22619170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.349142
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