Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya

BACKGROUND: Resistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and has spread worldwide. SP remains the recommended drug for intermittent preventive treatment fo...

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Main Authors: Iriemenam, Nnaemeka C, Shah, Monica, Gatei, Wangeci, van Eijk, Anna M, Ayisi, John, Kariuki, Simon, Vanden Eng, Jodi, Owino, Simon O, Lal, Ashima A, Omosun, Yusuf O, Otieno, Kephas, Desai, Meghna, ter Kuile, Feiko O, Nahlen, Bernard, Moore, Julie, Hamel, Mary J, Ouma, Peter, Slutsker, Laurence, Shi, Ya Ping
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390272/
https://ncbi.nlm.nih.gov/pubmed/22540158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-134
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