Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya

BACKGROUND: Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis. Since mefloquine is being considered as a replacement for sulfadoxine/pyrimethamine in this vulnerable pop...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Green, Michael, Otieno, Kephas, Katana, Abraham, Slutsker, Laurence, Kariuki, Simon, Ouma, Peter, González, Raquel, Menendez, Clara, ter Kuile, Feiko, Desai, Meghna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700759/
https://ncbi.nlm.nih.gov/pubmed/26732683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-1049-9
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