Small RNA-Mediated Epigenetic Myostatin Silencing

Myostatin (Mstn) is a secreted growth factor that negatively regulates muscle mass and is therefore a potential pharmacological target for the treatment of muscle wasting disorders such as Duchenne muscular dystrophy. Here we describe a novel Mstn blockade approach in which small interfering RNAs (s...

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Autors principals: Roberts, Thomas C, Andaloussi, Samir EL, Morris, Kevin V, McClorey, Graham, Wood, Matthew JA
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390243/
https://ncbi.nlm.nih.gov/pubmed/23344003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.15
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