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Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells

Ex vivo expansion of hematopoietic stem cells (HSCs) depends on HSC self-renewing proliferation and functional maintenance, which can be negatively affected by HSC differentiation, apoptosis, and senescence. Therefore, inhibition of HSC senescence may promote HSC expansion. To test this hypothesis,...

詳細記述

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書誌詳細
主要な著者: Zou, Jing, Zou, Ping, Wang, Jie, Li, Lei, Wang, Yong, Zhou, Daohong, Liu, Lingbo
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390192/
https://ncbi.nlm.nih.gov/pubmed/22258328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-011-1397-7
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