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Modelling oncogenic Ras/Raf signalling in the mouse

The Ras/Raf/MEK/ERK (or MAPK) signalling pathway relays extracellular stimuli to the nucleus, thereby regulating diverse cellular responses such as proliferation, growth, differentiation and apoptosis. Perturbation of these processes by aberrant MAPK signalling often leads to malignant transformatio...

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Detalles Bibliográficos
Main Authors: Karreth, Florian, Tuveson, David A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389704/
https://ncbi.nlm.nih.gov/pubmed/19201597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2008.12.006
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