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DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences
The natural product leinamycin has been found to produce abasic sites in duplex DNA through the hydrolysis of the glycosidic bond of guanine residues modified by this drug. In the present study, using a synthetic oligonucleotide duplex, we demonstrate spontaneous DNA strand cleavage at leinamycin-in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3389147/ https://ncbi.nlm.nih.gov/pubmed/22682923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.033 |
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