Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethylepipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents

Two conjugates (1 and 2) of camptothecin (CPT) and 4β-anilino-4′-O-demethylepipodophyllotoxin were previously shown to exert antitumor activity through inhibition of topoisomerase I (topo I). In this current study, two novel conjugates (1E and 2E) with an open E-ring in the CPT moiety were first syn...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ye, Deyong, Shi, Qian, Leung, Chung-Hang, Kim, Seung-Whan, Park, Shin-Young, Gullen, Elizabeth A., Jiang, Zao Li, Zhu, Hao, Morris-Natschke, Susan L., Cheng, Yung-Chi, Lee, Kuo-Hsiung
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389137/
https://ncbi.nlm.nih.gov/pubmed/22698783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.030
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