The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

The CSF-1 receptor (CSF-1R) regulates CNS microglial development. However, the localization and developmental roles of this receptor and its ligands, IL-34 and CSF-1, in the brain are poorly understood. Here we show that compared to wild type mice, CSF-1R-deficient (Csf1r−/−) mice have smaller brain...

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Detalhes bibliográficos
Main Authors: Nandi, Sayan, Gokhan, Solen, Dai, Xu-Ming, Wei, Suwen, Enikolopov, Grigori, Lin, Haishan, Mehler, Mark F., Stanley, E. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388946/
https://ncbi.nlm.nih.gov/pubmed/22542597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2012.03.026
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