SUMOylation of Blimp-1 is critical for plasma cell differentiation

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcr...

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Main Authors: Ying, Hsia-Yuan, Su, Shin-Tang, Hsu, Pang-Hung, Chang, Che-Chang, Lin, I-Ying, Tseng, Yu-Hsuan, Tsai, Ming-Daw, Shih, Hsiu-Ming, Lin, Kuo-I
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388782/
https://ncbi.nlm.nih.gov/pubmed/22555612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.60
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