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Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host range determinant since it mediates virus binding to host-specific cellular receptors(1–3). Here, we therefore as...

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Detalhes bibliográficos
Main Authors: Imai, Masaki, Watanabe, Tokiko, Hatta, Masato, Das, Subash C., Ozawa, Makoto, Shinya, Kyoko, Zhong, Gongxun, Hanson, Anthony, Katsura, Hiroaki, Watanabe, Shinji, Li, Chengjun, Kawakami, Eiryo, Yamada, Shinya, Kiso, Maki, Suzuki, Yasuo, Maher, Eileen A., Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388103/
https://ncbi.nlm.nih.gov/pubmed/22722205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10831
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