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Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies

Patch-clamp recordings in single-cell expression systems have been traditionally used to study the function of ion channels. However, this experimental setting does not enable assessment of tissue-level function such as action potential (AP) conduction. Here we introduce a biosynthetic system that p...

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Hlavní autoři: Kirkton, Robert D., Bursac, Nenad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388000/
https://ncbi.nlm.nih.gov/pubmed/21556054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1302
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