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Engineering prokaryotic channels for control of mammalian tissue excitability

The ability to directly enhance electrical excitability of human cells is hampered by the lack of methods to efficiently overexpress large mammalian voltage-gated sodium channels (VGSC). Here we describe the use of small prokaryotic sodium channels (BacNa(v)) to create de novo excitable human tissue...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nguyen, Hung X., Kirkton, Robert D., Bursac, Nenad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071848/
https://ncbi.nlm.nih.gov/pubmed/27752065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13132
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