Inhibition of Acid Sensing Ion Channel Currents by Lidocaine in Cultured Mouse Cortical Neurons

BACKGROUND: Lidocaine is a local anesthetic that has multiple pharmacological effects including antiarrhythmia, antinociception, and neuroprotection. Acid sensing ion channels (ASICs) are proton-gated cation channels that belong to the epithelial sodium channel/degenerin superfamily. Activation of A...

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Hlavní autoři: Lin, Jun, Chu, Xiangping, Maysami, Samaneh, Li, Minghua, Si, Hongfang, Cottrell, James E., Simon, Roger P., Xiong, Zhigang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387555/
https://ncbi.nlm.nih.gov/pubmed/21385979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e31820a511c
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