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Intramolecular Epistasis and the Evolution of a New Enzymatic Function

Atrazine chlorohydrolase (AtzA) and its close relative melamine deaminase (TriA) differ by just nine amino acid substitutions but have distinct catalytic activities. Together, they offer an informative model system to study the molecular processes that underpin the emergence of new enzymatic functio...

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Détails bibliographiques
Auteurs principaux: Noor, Sajid, Taylor, Matthew C., Russell, Robyn J., Jermiin, Lars S., Jackson, Colin J., Oakeshott, John G., Scott, Colin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387218/
https://ncbi.nlm.nih.gov/pubmed/22768133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039822
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