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Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology
We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3387198/ https://ncbi.nlm.nih.gov/pubmed/22768057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039052 |
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