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Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

Infarction occurs when myocardial perfusion is interrupted for prolonged periods of time. Short episodes of ischemia and reperfusion protect against tissue injury when the heart is subjected to a subsequent prolonged ischemic episode, a phenomenon known as ischemic preconditioning (IPC). Hypoxia-ind...

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Main Authors: Sarkar, Kakali, Cai, Zheqing, Gupta, Rigu, Parajuli, Nirmal, Fox-Talbot, Karen, Darshan, Medha S., Gonzalez, Frank J., Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387090/
https://ncbi.nlm.nih.gov/pubmed/22699503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208314109
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