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Loss of the SxxSS Motif in a Human T-Cell Factor-4 Isoform Confers Hypoxia Resistance to Liver Cancer: An Oncogenic Switch in Wnt Signaling

PURPOSE: Aberrantly activated Wnt/β-catenin signaling is important in hepatocellular carcinoma (HCC) development. Downstream gene expressions involving the Wnt/β-catenin cascade occur through T-cell factor (TCF) proteins. Here, we show the oncogenic potential of human TCF-4 isoforms based on the exp...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koga, Hironori, Tsedensodnom, Orkhontuya, Tomimaru, Yoshito, Walker, Evan J., Lee, Han Chu, Kim, Kang Mo, Yano, Hirohisa, Wands, Jack R., Kim, Miran
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386968/
https://ncbi.nlm.nih.gov/pubmed/22768190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039981
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