MMP-8 Deficiency Increases TLR/RAGE Ligands S100A8 and S100A9 and Exacerbates Lung Inflammation during Endotoxemia

Matrix metalloproteinase-8, released mainly from neutrophils, is a critical regulator of the inflammatory response by its ability to cleave multiple mediators. Herein, we report the results of a model of endotoxemia after intraperitoneal LPS injection in mice lacking MMP-8 and their wildtype counter...

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Detalhes bibliográficos
Main Authors: González-López, Adrián, Aguirre, Alina, López-Alonso, Inés, Amado, Laura, Astudillo, Aurora, Fernández-García, María Soledad, Suárez, María F., Batalla-Solís, Estefanía, Colado, Enrique, Albaiceta, Guillermo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386945/
https://ncbi.nlm.nih.gov/pubmed/22768176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039940
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