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An efficient multi-locus mixed model approach for genome-wide association studies in structured populations

Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but do no...

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Detaylı Bibliyografya
Asıl Yazarlar: Segura, Vincent, Vilhjálmsson, Bjarni J., Platt, Alexander, Korte, Arthur, Seren, Ümit, Long, Quan, Nordborg, Magnus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386481/
https://ncbi.nlm.nih.gov/pubmed/22706313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2314
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