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An efficient multi-locus mixed model approach for genome-wide association studies in structured populations
Population structure causes genome-wide linkage disequilibrium between unlinked loci, leading to statistical confounding in genome-wide association studies. Mixed models have been shown to handle the confounding effects of a diffuse background of large numbers of loci of small effect well, but do no...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386481/ https://ncbi.nlm.nih.gov/pubmed/22706313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2314 |
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