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Distinct roles of mitochondria- and ER-localized Bcl-x(L) in apoptosis resistance and Ca(2+) homeostasis
Bcl-2 proteins are major regulators of cellular responses to intrinsic and extrinsic apoptotic stimuli. Among them, overexpression of the antiapoptotic protein Bcl-x(L) modulates intracellular Ca(2+) homeostasis and organelle-specific apoptotic signaling pathways. However, the specific activities of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386223/ https://ncbi.nlm.nih.gov/pubmed/22573883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-02-0090 |
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