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Microtubules regulate GEF-H1 in response to extracellular matrix stiffness
Breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated contractility. In turn, matrix stiffness regulates RhoA activity. However, the upstream signaling mechanisms are poorly defined. Here we demonstrate that the Rho exchange factor GEF-H1 mediates RhoA activati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386221/ https://ncbi.nlm.nih.gov/pubmed/22593214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-10-0876 |
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