Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts. When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a r...

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Bibliografiske detaljer
Main Authors: Kisseleva, Tatiana, Cong, Min, Paik, YongHan, Scholten, David, Jiang, Chunyan, Benner, Chris, Iwaisako, Keiko, Moore-Morris, Thomas, Scott, Brian, Tsukamoto, Hidekazu, Evans, Sylvia M., Dillmann, Wolfgang, Glass, Christopher K., Brenner, David A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386114/
https://ncbi.nlm.nih.gov/pubmed/22566629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201840109
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