Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts. When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a r...

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Main Authors: Kisseleva, Tatiana, Cong, Min, Paik, YongHan, Scholten, David, Jiang, Chunyan, Benner, Chris, Iwaisako, Keiko, Moore-Morris, Thomas, Scott, Brian, Tsukamoto, Hidekazu, Evans, Sylvia M., Dillmann, Wolfgang, Glass, Christopher K., Brenner, David A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386114/
https://ncbi.nlm.nih.gov/pubmed/22566629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201840109
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