New antimalarial indolone-N-oxides, generating radical species, destabilize the host cell membrane at early stages of Plasmodium falciparum growth: role of band 3 tyrosine phosphorylation

Although indolone-N-oxide (INODs) genereting long-lived radicals possess antiplasmodial activity in the low-nanomolar range, little is known about their mechanism of action. To explore the molecular basis of INOD activity, we screened for changes in INOD-treated malaria-infected erythrocytes (Pf-RBC...

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Main Authors: Pantaleo, Antonella, Ferru, Emanuela, Vono, Rosa, Giribaldi, Giuliana, Lobina, Omar, Nepveu, Françoise, Ibrahim, Hany, Nallet, Jean-Pierre, Carta, Franco, Mannu, Franca, Pippia, Proto, Campanella, Estela, Low, Philip S., Turrini, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385926/
https://ncbi.nlm.nih.gov/pubmed/22142474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.11.008
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