Deletion of the BDNF Truncated Receptor TrkB.T1 Delays Disease Onset in a Mouse Model of Amyotrophic Lateral Sclerosis

Brain Derived Neurotrophic Factor (BDNF) exerts strong pro-survival effects on developing and injured motoneurons. However, in clinical trials, BDNF has failed to benefit patients with amyotrophic lateral sclerosis (ALS). To date, the cause of this failure remains unclear. Motoneurons express the Tr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yanpallewar, Sudhirkumar U., Barrick, Colleen A., Buckley, Hannah, Becker, Jodi, Tessarollo, Lino
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384607/
https://ncbi.nlm.nih.gov/pubmed/22761934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039946
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak