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Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application

The mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation, survival, and autophagy. The mTOR pathway is frequently activate...

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Bibliografske podrobnosti
Main Authors: Zhao, Yongchao, Sun, Yi
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384423/
https://ncbi.nlm.nih.gov/pubmed/22745582
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