Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells through up-regulating glutaminase (GLS). Glutamine is converted to glutamate by GLS, entering the tricarboxylic acid cycle as an important energy...

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Bibliographic Details
Main Authors: Liu, Wei, Le, Anne, Hancock, Chad, Lane, Andrew N., Dang, Chi V., Fan, Teresa W.-M., Phang, James M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384197/
https://ncbi.nlm.nih.gov/pubmed/22615405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203244109
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