Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment (HM) control HSC activity during regenerative hematopoiesis. Connexin-43 (Cx43), a connexin constituent of gap junctions...

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Bibliografiska uppgifter
Huvudupphovsmän: Taniguchi Ishikawa, Eri, Gonzalez-Nieto, Daniel, Ghiaur, Gabriel, Dunn, Susan K., Ficker, Ashley M., Murali, Bhuvana, Madhu, Malav, Gutstein, David E., Fishman, Glenn I., Barrio, Luis C., Cancelas, Jose A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384185/
https://ncbi.nlm.nih.gov/pubmed/22611193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120358109
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