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Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells
Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment (HM) control HSC activity during regenerative hematopoiesis. Connexin-43 (Cx43), a connexin constituent of gap junctions...
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Main Authors: | , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
National Academy of Sciences
2012
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384185/ https://ncbi.nlm.nih.gov/pubmed/22611193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120358109 |
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