H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. Here we combine quantitative mass spectrometry, ChIP deep-sequencing, and functional studies to determine the role of hist...

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Detalhes bibliográficos
Main Authors: Chicas, Agustin, Kapoor, Avnish, Wang, Xiaowo, Aksoy, Ozlem, Evertts, Adam G., Zhang, Michael Q., Garcia, Benjamin A., Bernstein, Emily, Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384172/
https://ncbi.nlm.nih.gov/pubmed/22615382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119836109
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