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Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control
The RecBCD enzyme is a complex heterotrimeric helicase/nuclease that initiates recombination at double-stranded DNA breaks. In Escherichia coli, its activities are regulated by the octameric recombination hotspot, χ (5′-GCTGGTGG), which is read as a single-stranded DNA sequence while the enzyme is u...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384165/ https://ncbi.nlm.nih.gov/pubmed/22603793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206081109 |
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